The increasingly complex interplay between corporate fast food and non-Western societies took a new and troubling turn recently with the launch of Burger King's “Whopper Virgins” advertising campaign. This series of web and television ads showcasing the company's iconic flame-broiled sandwich began airing in December 2008. In the commercials, selected participants, dubbed “virgins” since they have purportedly never been exposed to industry marketing, much less eaten fast food hamburgers, are asked to sample both a Burger King Whopper and McDonald's Big Mac and then indicate which sandwich they like best. Problematically, taste-test participants are drawn from three widely known and geo-culturally distinct indigenous groups: the Hmong (China and mainland Southeast Asia), Inuit (Arctic Canada, Greenland, and Alaska), and Maramureş (northern Romania). Although commercials with depictions of indigenous groups are nothing new to U.S. television viewers, Burger King drew sharp public criticism almost immediately for using real tribal peoples as the focus of their “Whopper Virgins” promotion. Anthropology provides a useful vantage point from which to consider these advertisements given the taste-test participants’ traditional backgrounds and stated unfamiliarity with corporate fast food. Matejowsky provides a critical assessment of this marketing promotion by addressing (1) the various distortions that commonly inform portrayals of native populations in Western popular culture and (2) the relevance that anthropologists can bring to bear on the “Whopper Virgins” debate. Taken as a whole, this work reveals the thorny issues that can arise amid intersections of global fast food, U.S. popular culture, and indigenous populations.