Abstract

The identification and development of specific biological or chemical medicines to control bacteria and cure patients suffering from infectious disease was a major scientific innovation in medicine. But following widespread use of antimicrobials, bacterial resistance emerged and spread toward an increasing number of antibiotics. Worldwide antibiotic abuse plays an important role in the selection of antimicrobial resistance (AMR) that is a global threat against public health. Declining supplies of new antibiotics strengthens this concern. Strategies for counteracting the threatening inability of antibiotics to control infectious disease are based on the approach to ‘think globally while acting locally.’